An unlikely renaissance is occurring in biological imaging, propelled by the ongoing development of serial block-face electron microscopy imaging technologies. Imaging systems based on scanning EM instruments place large-volume automated EM serial imaging within reach of most labs.
How best to take advantage of the automation and versatility? Large-scale connectomicsstudies are stunning in their scope and detail. Smaller-scale SBFI applications, however, offer academic labs and preclinical researchers opportunities to make new discoveries, measure new outcomes, and detect toxic changes in comparatively unbiased experiments. In this webcastwe discuss today's large volume SBFI technologies, some novel applications that are in current use, and consider how the expanding size of possible specimens is promoting faster throughput imaging.